Netcare 911 paramedics and other services responded to an accident on Houtkop Road in Vereeniging this morning.
Upon their arrival on scene they found that a two vehicles were involved in a side-impact accident.
One person sustained serious injuries while another person sustained moderate injuries.
Both patients were treated on scene before they were transported to hospital for further medical care.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation.